Hereditary cancer susceptibility

Challenges associated with hereditary cancer susceptibility testing.

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Susceptibility Genes in Hereditary Breast Cancer

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Hereditary Breast Cancer: The Era of New Susceptibility Genes

Breast cancer is the most common malignancy among females. 5%-10% of breast cancer cases are hereditary and are caused by pathogenic mutations in the considered reference BRCA1 and BRCA2 genes. As sequencing technologies evolve, more susceptible genes have been discovered and BRCA1 and BRCA2 predisposition seems to be only a part of the story. These new findings include rare germline mutations ...

DNA repair pathways and hereditary cancer susceptibility syndromes.

Every living organism is exposed to numerous genomic insults on a daily basis as a consequence of cellular metabolism and exposure to environmental agents capable of interacting with the genome (e.g. chemicals, toxins, pollutants, UV and ionizing radiation) (1). Maintenance of the integrity of the genome is paramount to the survival and propagation of a species and involves the continuous activ...

Pattern of hereditary susceptibility in rheumatic fever.